Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine
Identifieur interne : 002229 ( Main/Exploration ); précédent : 002228; suivant : 002230Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine
Auteurs : Anthony Laugeray [France] ; Jean-Marie Launay [France] ; Jacques Callebert [France] ; Oguz Mutlu [France, Turquie] ; Gilles J. Guillemin [Australie] ; Catherine Belzung [France] ; Pascal R. Barone [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antidépresseurs de seconde génération (pharmacologie), Cynurénine (métabolisme), Cytokines (métabolisme), Dépression (), Dépression (physiopathologie), Facteurs temps, Fluoxétine (pharmacologie), Indoleamine-pyrrole 2,3,-dioxygenase (antagonistes et inhibiteurs), Indoleamine-pyrrole 2,3,-dioxygenase (métabolisme), Maladie chronique, Mâle, Médiateurs de l'inflammation (métabolisme), Souris de lignée BALB C, Stress psychologique (), Stress psychologique (physiopathologie), Transduction du signal (), Tryptophane (analogues et dérivés), Tryptophane (pharmacologie).
- MESH :
- analogues et dérivés : Tryptophane.
- antagonistes et inhibiteurs : Indoleamine-pyrrole 2,3,-dioxygenase.
- métabolisme : Cynurénine, Cytokines, Indoleamine-pyrrole 2,3,-dioxygenase, Médiateurs de l'inflammation.
- pharmacologie : Antidépresseurs de seconde génération, Fluoxétine, Tryptophane.
- physiopathologie : Dépression, Stress psychologique.
- Animaux, Dépression, Facteurs temps, Maladie chronique, Mâle, Souris de lignée BALB C, Stress psychologique, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Antidepressive Agents, Second-Generation (pharmacology), Chronic Disease, Cytokines (metabolism), Depression (physiopathology), Depression (prevention & control), Fluoxetine (pharmacology), Indoleamine-Pyrrole 2,3,-Dioxygenase (antagonists & inhibitors), Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism), Inflammation Mediators (metabolism), Kynurenine (metabolism), Male, Mice, Inbred BALB C, Signal Transduction (drug effects), Stress, Psychological (physiopathology), Stress, Psychological (prevention & control), Time Factors, Tryptophan (analogs & derivatives), Tryptophan (pharmacology).
- MESH :
- chemical , analogs & derivatives : Tryptophan.
- chemical , antagonists & inhibitors : Indoleamine-Pyrrole 2,3,-Dioxygenase.
- chemical , metabolism : Cytokines, Indoleamine-Pyrrole 2,3,-Dioxygenase, Inflammation Mediators, Kynurenine.
- chemical , pharmacology : Antidepressive Agents, Second-Generation, Fluoxetine, Tryptophan.
- drug effects : Signal Transduction.
- physiopathology : Depression, Stress, Psychological.
- prevention & control : Depression, Stress, Psychological.
- Animals, Chronic Disease, Male, Mice, Inbred BALB C, Time Factors.
Abstract
We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure—a validated model of stress-induced depression—results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify the glutamatergic neurotransmission through the imbalance between downstream metabolites such as 3-hydroxykynurenine, quinolinic and kynurenic acids. We showed that daily treatment with the IDO1 inhibitor 1-methyl-D-tryptophan partially rescues UCMS-induced KP alterations as does the antidepressant fluoxetine. More importantly we demonstrated that 1-methyl-D-tryptophan was able to alleviate most of the behavioural changes resulting from UCMS exposure. We also showed that both fluoxetine and 1-methyl-D-tryptophan robustly reduced peripheral levels of proinflammatory cytokines in UCMS mice suggesting that their therapeutic effects might occur through anti-inflammatory processes. KP inhibition might be involved in the positive effects of fluoxetine on mice behaviour and could be a relevant strategy to counteract depressive-like symptoms.
Url:
DOI: 10.1371/journal.pone.0164337
PubMed: 27828964
PubMed Central: 5102430
Affiliations:
- Australie, France, Turquie
- Centre-Val de Loire, Nouvelle-Galles du Sud, Région Centre, Île-de-France
- Paris, Sydney, Tours
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Le document en format XML
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Comparison with Fluoxetine</title><author><name sortKey="Laugeray, Anthony" sort="Laugeray, Anthony" uniqKey="Laugeray A" first="Anthony" last="Laugeray">Anthony Laugeray</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Molecular and Experimental Immunology and Neurogenetics – UMR7355, CNRS - 3b Rue de Férollerie, Orléans La Source, Cedex 2, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Molecular and Experimental Immunology and Neurogenetics – UMR7355, CNRS - 3b Rue de Férollerie, Orléans La Source, Cedex 2</wicri:regionArea><wicri:noRegion>Cedex 2</wicri:noRegion><wicri:noRegion>Cedex 2</wicri:noRegion></affiliation></author><author><name sortKey="Launay, Jean Marie" sort="Launay, Jean Marie" uniqKey="Launay J" first="Jean-Marie" last="Launay">Jean-Marie Launay</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>UMRS INSERM U942, Service de Biochimie, Hôpital Lariboisière, Assistance Publique — Hôpitaux de Paris, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMRS INSERM U942, Service de Biochimie, Hôpital Lariboisière, Assistance Publique — Hôpitaux de Paris, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Callebert, Jacques" sort="Callebert, Jacques" uniqKey="Callebert J" first="Jacques" last="Callebert">Jacques Callebert</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>UMRS INSERM U942, Service de Biochimie, Hôpital Lariboisière, Assistance Publique — Hôpitaux de Paris, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMRS INSERM U942, Service de Biochimie, Hôpital Lariboisière, Assistance Publique — Hôpitaux de Paris, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mutlu, Oguz" sort="Mutlu, Oguz" uniqKey="Mutlu O" first="Oguz" last="Mutlu">Oguz Mutlu</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>UMRS INSERM U930, CNRS ERL 3106, Université François Rabelais, Tours, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMRS INSERM U930, CNRS ERL 3106, Université François Rabelais, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Pharmacology, Faculty of Medicine, Kocaeli University, 41380 Kocaeli, Turkey</addr-line></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pharmacology, Faculty of Medicine, Kocaeli University, 41380 Kocaeli</wicri:regionArea><wicri:noRegion>41380 Kocaeli</wicri:noRegion></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Belzung, Catherine" sort="Belzung, Catherine" uniqKey="Belzung C" first="Catherine" last="Belzung">Catherine Belzung</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>UMRS INSERM U930, CNRS ERL 3106, Université François Rabelais, Tours, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMRS INSERM U930, CNRS ERL 3106, Université François Rabelais, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Barone, Pascal R" sort="Barone, Pascal R" uniqKey="Barone P" first="Pascal R." last="Barone">Pascal R. Barone</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>UMRS INSERM U930, CNRS ERL 3106, Université François Rabelais, Tours, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMRS INSERM U930, CNRS ERL 3106, Université François Rabelais, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antidepressive Agents, Second-Generation (pharmacology)</term><term>Chronic Disease</term><term>Cytokines (metabolism)</term><term>Depression (physiopathology)</term><term>Depression (prevention & control)</term><term>Fluoxetine (pharmacology)</term><term>Indoleamine-Pyrrole 2,3,-Dioxygenase (antagonists & inhibitors)</term><term>Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism)</term><term>Inflammation Mediators (metabolism)</term><term>Kynurenine (metabolism)</term><term>Male</term><term>Mice, Inbred BALB C</term><term>Signal Transduction (drug effects)</term><term>Stress, Psychological (physiopathology)</term><term>Stress, Psychological (prevention & control)</term><term>Time Factors</term><term>Tryptophan (analogs & derivatives)</term><term>Tryptophan (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antidépresseurs de seconde génération (pharmacologie)</term><term>Cynurénine (métabolisme)</term><term>Cytokines (métabolisme)</term><term>Dépression ()</term><term>Dépression (physiopathologie)</term><term>Facteurs temps</term><term>Fluoxétine (pharmacologie)</term><term>Indoleamine-pyrrole 2,3,-dioxygenase (antagonistes et inhibiteurs)</term><term>Indoleamine-pyrrole 2,3,-dioxygenase (métabolisme)</term><term>Maladie chronique</term><term>Mâle</term><term>Médiateurs de l'inflammation (métabolisme)</term><term>Souris de lignée BALB C</term><term>Stress psychologique ()</term><term>Stress psychologique (physiopathologie)</term><term>Transduction du signal ()</term><term>Tryptophane (analogues et dérivés)</term><term>Tryptophane (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Tryptophan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Indoleamine-Pyrrole 2,3,-Dioxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Indoleamine-Pyrrole 2,3,-Dioxygenase</term><term>Inflammation Mediators</term><term>Kynurenine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antidepressive Agents, Second-Generation</term><term>Fluoxetine</term><term>Tryptophan</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Tryptophane</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Indoleamine-pyrrole 2,3,-dioxygenase</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cynurénine</term><term>Cytokines</term><term>Indoleamine-pyrrole 2,3,-dioxygenase</term><term>Médiateurs de l'inflammation</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antidépresseurs de seconde génération</term><term>Fluoxétine</term><term>Tryptophane</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Dépression</term><term>Stress psychologique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Depression</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Depression</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chronic Disease</term><term>Male</term><term>Mice, Inbred BALB C</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dépression</term><term>Facteurs temps</term><term>Maladie chronique</term><term>Mâle</term><term>Souris de lignée BALB C</term><term>Stress psychologique</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure—a validated model of stress-induced depression—results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify the glutamatergic neurotransmission through the imbalance between downstream metabolites such as 3-hydroxykynurenine, quinolinic and kynurenic acids. We showed that daily treatment with the IDO1 inhibitor 1-methyl-D-tryptophan partially rescues UCMS-induced KP alterations as does the antidepressant fluoxetine. More importantly we demonstrated that 1-methyl-D-tryptophan was able to alleviate most of the behavioural changes resulting from UCMS exposure. We also showed that both fluoxetine and 1-methyl-D-tryptophan robustly reduced peripheral levels of proinflammatory cytokines in UCMS mice suggesting that their therapeutic effects might occur through anti-inflammatory processes. KP inhibition might be involved in the positive effects of fluoxetine on mice behaviour and could be a relevant strategy to counteract depressive-like symptoms.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dantzer, R" uniqKey="Dantzer R">R Dantzer</name></author><author><name sortKey="O Connor, Jc" uniqKey="O Connor J">JC O'Connor</name></author><author><name sortKey="Lawson, Ma" uniqKey="Lawson M">MA Lawson</name></author><author><name sortKey="Kelley, Kw" uniqKey="Kelley K">KW Kelley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Myint, Am" uniqKey="Myint A">AM Myint</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarcz, R" uniqKey="Schwarcz R">R Schwarcz</name></author><author><name sortKey="Bruno, Jp" uniqKey="Bruno J">JP Bruno</name></author><author><name sortKey="Muchowski, Pj" uniqKey="Muchowski P">PJ Muchowski</name></author><author><name 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I">IP Lapin</name></author><author><name sortKey="Mutovkina, Lg" uniqKey="Mutovkina L">LG Mutovkina</name></author><author><name sortKey="Ryzov, Iv" uniqKey="Ryzov I">IV Ryzov</name></author><author><name sortKey="Mirzaev, S" uniqKey="Mirzaev S">S Mirzaev</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Turquie</li></country><region><li>Centre-Val de Loire</li><li>Nouvelle-Galles du Sud</li><li>Région Centre</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Sydney</li><li>Tours</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Laugeray, Anthony" sort="Laugeray, Anthony" uniqKey="Laugeray A" first="Anthony" last="Laugeray">Anthony Laugeray</name></noRegion><name sortKey="Barone, Pascal R" sort="Barone, Pascal R" uniqKey="Barone P" first="Pascal R." last="Barone">Pascal R. Barone</name><name sortKey="Belzung, Catherine" sort="Belzung, Catherine" uniqKey="Belzung C" first="Catherine" last="Belzung">Catherine Belzung</name><name sortKey="Callebert, Jacques" sort="Callebert, Jacques" uniqKey="Callebert J" first="Jacques" last="Callebert">Jacques Callebert</name><name sortKey="Launay, Jean Marie" sort="Launay, Jean Marie" uniqKey="Launay J" first="Jean-Marie" last="Launay">Jean-Marie Launay</name><name sortKey="Mutlu, Oguz" sort="Mutlu, Oguz" uniqKey="Mutlu O" first="Oguz" last="Mutlu">Oguz Mutlu</name></country><country name="Turquie"><noRegion><name sortKey="Mutlu, Oguz" sort="Mutlu, Oguz" uniqKey="Mutlu O" first="Oguz" last="Mutlu">Oguz Mutlu</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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